ResearchGate	Satoshi Kaneko

研究キーワード	research interests	Vaccinology,Machine Learning,Proteomics,Virology	Vaccinology,Machine Learning,Proteomics,Virology

研究分野	research research_areas	ウイルス学,分子生物学,免疫学,薬系化学、創薬科学	Virology,Molecular biology,Immunology,Pharmaceuticals - chemistry and drug development

学歴	education

経歴	experience	－ Doctoral degree Medical Sciences, Karolinska Institutet － Postdoctoral associate, National Emerging Infectious Diseases Laboratory (NEIDL), Boston University － Senior bioinformatician, National Bioinformatics Infrastructure (NBIS), SciLifeLab － Senior Bioinformatician, NEC Oncoimmunity － Associate professor, Department of Vaccine Informatics, School of Tropical Medicine (NEKKEN) － Doctoral degree Medical Sciences, Karolinska Institutet － Postdoctoral associate, National Emerging Infectious Diseases Laboratory (NEIDL), Boston University － Senior bioinformatician, National Bioinformatics Infrastructure (NBIS), SciLifeLab － Senior Bioinformatician, NEC Oncoimmunity － Associate professor, Department of Vaccine Informatics, School of Tropical Medicine (NEKKEN)

委員歴	committee memberships

所属学協会	association memberships

受賞	awards

論文	papers	SARS-CoV-2 and HSV-1 Induce Amyloid Aggregation in Human CSF Resulting in Drastic Soluble Protein Depletion. Wanda Christ,Sebastian Kapell,Michal J Sobkowiak,Georgios Mermelekas,Björn Evertsson,Helena Sork,Osama Saher,Safa Bazaz,Oskar Gustafsson,Eduardo I Cardenas,Viviana Villa,Roberta Ricciarelli,Johan K Sandberg,Jonas Bergquist,Andrea Sturchio,Per Svenningsson,Tarja Malm,Alberto J Espay,Maria Pernemalm,Anders Lindén,Jonas Klingström,Samir El Andaloussi,Kariem Ezzat ACS chemical neuroscience 15巻22号4095頁-4104頁 2024年11月20日 Cell culture systems for isolation of SARS-CoV-2 clinical isolates and generation of recombinant virus. Da-Yuan Chen,Jacquelyn Turcinovic,Shuchen Feng,Devin J Kenney,Chue Vin Chin,Manish C Choudhary,Hasahn L Conway,Marc Semaan,Brianna J Close,Alexander H Tavares,Scott Seitz,Nazimuddin Khan,Sebastian Kapell,Nicholas A Crossland,Jonathan Z Li,Florian Douam,Susan C Baker,John H Connor,Mohsan Saeed iScience 26巻5号106634頁-106634頁 2023年05月19日 N-terminome analyses underscore the prevalence of SPPL3-mediated intramembrane proteolysis among Golgi-resident enzymes and its role in Golgi enzyme secretion. Laura Hobohm,Tomas Koudelka,Fenja H Bahr,Jule Truberg,Sebastian Kapell,Sarah-Sophie Schacht,Daniel Meisinger,Marion Mengel,Alexander Jochimsen,Anna Hofmann,Lukas Heintz,Andreas Tholey,Matthias Voss Cellular and molecular life sciences : CMLS 79巻3号185頁-185頁 2022年03月13日 DNA templates with blocked long 3' end single-stranded overhangs (BL3SSO) promote bona fide Cas9-stimulated homology-directed repair of long transgenes into endogenous gene loci. Saptaparni Bandyopadhyay,Joseph Douglass,Sebastian Kapell,Nazimuddin Khan,Fabiana Feitosa-Suntheimer,Jenny A Klein,Jasmine Temple,Jayce Brown-Culbertson,Alexander H Tavares,Mohsan Saeed,Nelson C Lau G3 (Bethesda, Md.) 11巻8号 2021年08月07日 Large-scale identification of protein histidine methylation in human cells. Sebastian Kapell,Magnus E Jakobsson NAR genomics and bioinformatics 3巻2号lqab045頁- 2021年06月 SARS-CoV-2 desensitizes host cells to interferon through inhibition of the JAK-STAT pathway. Da-Yuan Chen,Nazimuddin Khan,Brianna J Close,Raghuveera K Goel,Benjamin Blum,Alexander H Tavares,Devin Kenney,Hasahn L Conway,Jourdan K Ewoldt,Sebastian Kapell,Vipul C Chitalia,Nicholas A Crossland,Christopher S Chen,Darrell N Kotton,Susan C Baker,John H Connor,Florian Douam,Andrew Emili,Mohsan Saeed bioRxiv : the preprint server for biology 2020年10月28日 Defining the proteolytic landscape during enterovirus infection. Mohsan Saeed,Sebastian Kapell,Nicholas T Hertz,Xianfang Wu,Kierstin Bell,Alison W Ashbrook,Milica Tesic Mark,Henry A Zebroski,Maxwell L Neal,Malin Flodström-Tullberg,Margaret R MacDonald,John D Aitchison,Henrik Molina,Charles M Rice PLoS pathogens 16巻9号e1008927頁- 2020年09月 New Coxsackievirus 2Apro and 3Cpro protease antibodies for virus detection and discovery of pathogenic mechanisms. Olli H Laitinen,Emma Svedin,Sebastian Kapell,Minna M Hankaniemi,Pär G Larsson,Erna Domsgen,Virginia M Stone,Juha A E Määttä,Heikki Hyöty,Vesa P Hytönen,Malin Flodström-Tullberg Journal of virological methods 255巻29頁-37頁 2018年05月 Enteroviral proteases: structure, host interactions and pathogenicity. Olli H Laitinen,Emma Svedin,Sebastian Kapell,Anssi Nurminen,Vesa P Hytönen,Malin Flodström-Tullberg Reviews in medical virology 26巻4号251頁-67頁 2016年07月 Coxsackievirus counters the host innate immune response by blocking type III interferon expression. Katharina Lind,Emma Svedin,Erna Domsgen,Sebastian Kapell,Olli H Laitinen,Markus Moll,Malin Flodström-Tullberg The Journal of general virology 97巻6号1368頁-1380頁 2016年06月 SARS-CoV-2 and HSV-1 Induce Amyloid Aggregation in Human CSF Resulting in Drastic Soluble Protein Depletion. Wanda Christ,Sebastian Kapell,Michal J Sobkowiak,Georgios Mermelekas,Björn Evertsson,Helena Sork,Osama Saher,Safa Bazaz,Oskar Gustafsson,Eduardo I Cardenas,Viviana Villa,Roberta Ricciarelli,Johan K Sandberg,Jonas Bergquist,Andrea Sturchio,Per Svenningsson,Tarja Malm,Alberto J Espay,Maria Pernemalm,Anders Lindén,Jonas Klingström,Samir El Andaloussi,Kariem Ezzat ACS chemical neuroscience 15.22.4095-4104 2024/11/20 Cell culture systems for isolation of SARS-CoV-2 clinical isolates and generation of recombinant virus. Da-Yuan Chen,Jacquelyn Turcinovic,Shuchen Feng,Devin J Kenney,Chue Vin Chin,Manish C Choudhary,Hasahn L Conway,Marc Semaan,Brianna J Close,Alexander H Tavares,Scott Seitz,Nazimuddin Khan,Sebastian Kapell,Nicholas A Crossland,Jonathan Z Li,Florian Douam,Susan C Baker,John H Connor,Mohsan Saeed iScience 26.5.106634-106634 2023/05/19 N-terminome analyses underscore the prevalence of SPPL3-mediated intramembrane proteolysis among Golgi-resident enzymes and its role in Golgi enzyme secretion. Laura Hobohm,Tomas Koudelka,Fenja H Bahr,Jule Truberg,Sebastian Kapell,Sarah-Sophie Schacht,Daniel Meisinger,Marion Mengel,Alexander Jochimsen,Anna Hofmann,Lukas Heintz,Andreas Tholey,Matthias Voss Cellular and molecular life sciences : CMLS 79.3.185-185 2022/03/13 DNA templates with blocked long 3' end single-stranded overhangs (BL3SSO) promote bona fide Cas9-stimulated homology-directed repair of long transgenes into endogenous gene loci. Saptaparni Bandyopadhyay,Joseph Douglass,Sebastian Kapell,Nazimuddin Khan,Fabiana Feitosa-Suntheimer,Jenny A Klein,Jasmine Temple,Jayce Brown-Culbertson,Alexander H Tavares,Mohsan Saeed,Nelson C Lau G3 (Bethesda, Md.) 11.8. 2021/08/07 Large-scale identification of protein histidine methylation in human cells. Sebastian Kapell,Magnus E Jakobsson NAR genomics and bioinformatics 3.2.lqab045- 2021/06 SARS-CoV-2 desensitizes host cells to interferon through inhibition of the JAK-STAT pathway. Da-Yuan Chen,Nazimuddin Khan,Brianna J Close,Raghuveera K Goel,Benjamin Blum,Alexander H Tavares,Devin Kenney,Hasahn L Conway,Jourdan K Ewoldt,Sebastian Kapell,Vipul C Chitalia,Nicholas A Crossland,Christopher S Chen,Darrell N Kotton,Susan C Baker,John H Connor,Florian Douam,Andrew Emili,Mohsan Saeed bioRxiv : the preprint server for biology 2020/10/28 Defining the proteolytic landscape during enterovirus infection. Mohsan Saeed,Sebastian Kapell,Nicholas T Hertz,Xianfang Wu,Kierstin Bell,Alison W Ashbrook,Milica Tesic Mark,Henry A Zebroski,Maxwell L Neal,Malin Flodström-Tullberg,Margaret R MacDonald,John D Aitchison,Henrik Molina,Charles M Rice PLoS pathogens 16.9.e1008927- 2020/09 New Coxsackievirus 2Apro and 3Cpro protease antibodies for virus detection and discovery of pathogenic mechanisms. Olli H Laitinen,Emma Svedin,Sebastian Kapell,Minna M Hankaniemi,Pär G Larsson,Erna Domsgen,Virginia M Stone,Juha A E Määttä,Heikki Hyöty,Vesa P Hytönen,Malin Flodström-Tullberg Journal of virological methods 255.29-37 2018/05 Enteroviral proteases: structure, host interactions and pathogenicity. Olli H Laitinen,Emma Svedin,Sebastian Kapell,Anssi Nurminen,Vesa P Hytönen,Malin Flodström-Tullberg Reviews in medical virology 26.4.251-67 2016/07 Coxsackievirus counters the host innate immune response by blocking type III interferon expression. Katharina Lind,Emma Svedin,Erna Domsgen,Sebastian Kapell,Olli H Laitinen,Markus Moll,Malin Flodström-Tullberg The Journal of general virology 97.6.1368-1380 2016/06

MISC

書籍等出版物	books

講演・口頭発表等	conference	Innovative vaccine development using machine learning International vaccinology course 2024年09月06日 Innovative vaccine development using machine learning International vaccinology course 2024/09/06

担当経験のある項目	teaching experience

Works

競争的資金等の研究課題	research grants	Vaccine development project for severe fever with thrombocytopenia syndrome virus (SFTSV) Coalition for Epidemic Preparedness Innovations (CEPI) Strategic Center of Biomedical Advanced Vaccine Research and Development for Preparedness and Response (SCARDA) Japan Agency for Medical Research and Development (AMED) Vaccine development project for severe fever with thrombocytopenia syndrome virus (SFTSV) Coalition for Epidemic Preparedness Innovations (CEPI) Strategic Center of Biomedical Advanced Vaccine Research and Development for Preparedness and Response (SCARDA) Japan Agency for Medical Research and Development (AMED)

特許	patents

社会貢献活動	social contribution

メディア報道	media_coverage

学術貢献活動	academic_contribution

その他	etc