研究キーワード	research interests

研究分野	research research_areas	細胞生物学	Cell biology

学歴	education

経歴	experience

委員歴	committee memberships	2025年07月 － 2026年06月 日本学術振興会 特別研究員等審査会審査委員 2024年07月 － 2025年06月 日本学術振興会 特別研究員等審査会審査委員 2025/07 － 2026/06 日本学術振興会 特別研究員等審査会審査委員 2024/07 － 2025/06 日本学術振興会 特別研究員等審査会審査委員

所属学協会	association memberships

受賞	awards

論文	papers	Runx2 in the Perichondrial Osteoblasts Enhances Terminal Differentiation of Chondrocytes Through Nell1 Induction. Xin Qin,Qing Jiang,Longfei Wu,Suemi Yabuta,Chiharu Sakane,Yuki Matsuo,Ziheng Zhang,Hisato Komori,Manyu Zhang,Kosei Ito,Toshihisa Komori International journal of molecular sciences 27巻3号1266頁- 2026年01月27日 Branch site mutated mice revealed distinct roles of two Runx2 isoforms in bone development. Qing Jiang,Manyu Zhang,Haoyunyan Jin,Ziheng Zhang,Chiharu Sakane,Yuki Matsuo,Simeng Lai,Wen Zhang,Huilin Yang,Toshihisa Komori,Xin Qin Frontiers in cell and developmental biology 14巻1770176頁-1770176頁 2026年 An Osteoblast-Specific Enhancer and Subenhancer Cooperatively Regulate Runx2 Expression in Chondrocytes. Yuki Matsuo,Xin Qin,Takeshi Moriishi,Viviane K S Kawata-Matsuura,Hisato Komori,Chiharu Sakane,Suemi Yabuta,Qing Jiang,Hitomi Kaneko,Kosei Ito,Mayo Shigeta,Takaya Abe,Toshihisa Komori International journal of molecular sciences 26巻4号 2025年02月14日 Roles of Sp7 in osteoblasts for the proliferation, differentiation, and osteocyte process formation Qing Jiang,Kenichi Nagano,Takeshi Moriishi,Hisato Komori,Chiharu Sakane,Yuki Matsuo,Zhiguo Zhang,Riko Nishimura,Kosei Ito,Xin Qin,Toshihisa Komori Journal of Orthopaedic Translation 47巻161頁-175頁 2024年07月 Runx2 Regulates Galnt3 and Fgf23 Expressions and Galnt3 Decelerates Osteoid Mineralization by Stabilizing Fgf23. Qing Jiang,Xin Qin,Takeshi Moriishi,Ryo Fukuyama,Shinichi Katsumata,Hiroshi Matsuzaki,Hisato Komori,Yuki Matsuo,Chiharu Sakane,Kosei Ito,Hironori Hojo,Shinsuke Ohba,Toshihisa Komori International journal of molecular sciences 25巻4号 2024年02月14日 Runx2 is required for bone matrix protein gene expression in committed osteoblasts in mice. Xin Qin,Qing Jiang,Hisato Komori,Chiharu Sakane,Ryo Fukuyama,Yuki Matsuo,Kosei Ito,Toshihiro Miyazaki,Toshihisa Komori Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 36巻10号2081頁-2095頁 2021年06月08日 Runx2 is essential for the transdifferentiation of chondrocytes into osteoblasts. Xin Qin,Qing Jiang,Kenichi Nagano,Takeshi Moriishi,Toshihiro Miyazaki,Hisato Komori,Kosei Ito,Klaus von der Mark,Chiharu Sakane,Hitomi Kaneko,Toshihisa Komori PLoS genetics 16巻11号e1009169頁- 2020年11月 Expression of a Constitutively Active Form of Hck in Chondrocytes Activates Wnt and Hedgehog Signaling Pathways, and Induces Chondrocyte Proliferation in Mice. Viviane K S Kawata Matsuura,Carolina Andrea Yoshida,Hisato Komori,Chiharu Sakane,Kei Yamana,Qing Jiang,Toshihisa Komori International journal of molecular sciences 21巻8号2682頁-2682頁 2020年04月12日 Runx2 is required for the proliferation of osteoblast progenitors and induces proliferation by regulating Fgfr2 and Fgfr3. Tetsuya Kawane,Xin Qin,Qing Jiang,Toshihiro Miyazaki,Hisato Komori,Carolina Andrea Yoshida,Viviane Keiko Dos Santos Matsuura-Kawata,Chiharu Sakane,Yuki Matsuo,Kazuhiro Nagai,Takafumi Maeno,Yuki Date,Riko Nishimura,Toshihisa Komori Scientific reports 8巻1号13551頁-13551頁 2018年09月10日 Measurement of lysine-specific demethylase-1 activity in the nuclear extracts by flow-injection based time-of-flight mass spectrometry. Chiharu Sakane,Hiromichi Ohta,Yoshihiro Shidoji Journal of clinical biochemistry and nutrition 56巻2号123頁-31頁 2015年03月 Runx2 in the Perichondrial Osteoblasts Enhances Terminal Differentiation of Chondrocytes Through Nell1 Induction. Xin Qin,Qing Jiang,Longfei Wu,Suemi Yabuta,Chiharu Sakane,Yuki Matsuo,Ziheng Zhang,Hisato Komori,Manyu Zhang,Kosei Ito,Toshihisa Komori International journal of molecular sciences 27.3.1266- 2026/01/27 Branch site mutated mice revealed distinct roles of two Runx2 isoforms in bone development. Qing Jiang,Manyu Zhang,Haoyunyan Jin,Ziheng Zhang,Chiharu Sakane,Yuki Matsuo,Simeng Lai,Wen Zhang,Huilin Yang,Toshihisa Komori,Xin Qin Frontiers in cell and developmental biology 14.1770176-1770176 2026 An Osteoblast-Specific Enhancer and Subenhancer Cooperatively Regulate Runx2 Expression in Chondrocytes. Yuki Matsuo,Xin Qin,Takeshi Moriishi,Viviane K S Kawata-Matsuura,Hisato Komori,Chiharu Sakane,Suemi Yabuta,Qing Jiang,Hitomi Kaneko,Kosei Ito,Mayo Shigeta,Takaya Abe,Toshihisa Komori International journal of molecular sciences 26.4. 2025/02/14 Roles of Sp7 in osteoblasts for the proliferation, differentiation, and osteocyte process formation Qing Jiang,Kenichi Nagano,Takeshi Moriishi,Hisato Komori,Chiharu Sakane,Yuki Matsuo,Zhiguo Zhang,Riko Nishimura,Kosei Ito,Xin Qin,Toshihisa Komori Journal of Orthopaedic Translation 47.161-175 2024/07 Runx2 Regulates Galnt3 and Fgf23 Expressions and Galnt3 Decelerates Osteoid Mineralization by Stabilizing Fgf23. Qing Jiang,Xin Qin,Takeshi Moriishi,Ryo Fukuyama,Shinichi Katsumata,Hiroshi Matsuzaki,Hisato Komori,Yuki Matsuo,Chiharu Sakane,Kosei Ito,Hironori Hojo,Shinsuke Ohba,Toshihisa Komori International journal of molecular sciences 25.4. 2024/02/14 Runx2 is required for bone matrix protein gene expression in committed osteoblasts in mice. Xin Qin,Qing Jiang,Hisato Komori,Chiharu Sakane,Ryo Fukuyama,Yuki Matsuo,Kosei Ito,Toshihiro Miyazaki,Toshihisa Komori Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 36.10.2081-2095 2021/06/08 Runx2 is essential for the transdifferentiation of chondrocytes into osteoblasts. Xin Qin,Qing Jiang,Kenichi Nagano,Takeshi Moriishi,Toshihiro Miyazaki,Hisato Komori,Kosei Ito,Klaus von der Mark,Chiharu Sakane,Hitomi Kaneko,Toshihisa Komori PLoS genetics 16.11.e1009169- 2020/11 Expression of a Constitutively Active Form of Hck in Chondrocytes Activates Wnt and Hedgehog Signaling Pathways, and Induces Chondrocyte Proliferation in Mice. Viviane K S Kawata Matsuura,Carolina Andrea Yoshida,Hisato Komori,Chiharu Sakane,Kei Yamana,Qing Jiang,Toshihisa Komori International journal of molecular sciences 21.8.2682-2682 2020/04/12 Runx2 is required for the proliferation of osteoblast progenitors and induces proliferation by regulating Fgfr2 and Fgfr3. Tetsuya Kawane,Xin Qin,Qing Jiang,Toshihiro Miyazaki,Hisato Komori,Carolina Andrea Yoshida,Viviane Keiko Dos Santos Matsuura-Kawata,Chiharu Sakane,Yuki Matsuo,Kazuhiro Nagai,Takafumi Maeno,Yuki Date,Riko Nishimura,Toshihisa Komori Scientific reports 8.1.13551-13551 2018/09/10 Measurement of lysine-specific demethylase-1 activity in the nuclear extracts by flow-injection based time-of-flight mass spectrometry. Chiharu Sakane,Hiromichi Ohta,Yoshihiro Shidoji Journal of clinical biochemistry and nutrition 56.2.123-31 2015/03 さらに表示する more

MISC	FLOW INJECTION ASSAY FOR MEASURING LYSINE-SPECIFIC DEMETHYLASE-1 (LSD1) ACTIVITY BY TIME-OF-FLIGHT MASS SPECTROMETRY Y. Shidoji,C. Sakane,H. Ohta ANNALS OF NUTRITION AND METABOLISM 63巻363頁-363頁 2013年 FLOW INJECTION ASSAY FOR MEASURING LYSINE-SPECIFIC DEMETHYLASE-1 (LSD1) ACTIVITY BY TIME-OF-FLIGHT MASS SPECTROMETRY Y. Shidoji,C. Sakane,H. Ohta ANNALS OF NUTRITION AND METABOLISM 63.363-363 2013

書籍等出版物	books

講演・口頭発表等	conference

担当経験のある項目	teaching experience

Works

競争的資金等の研究課題	research grants	マウス生体でI型コラーゲン遺伝子発現を骨芽細胞特異的に制御するエンハンサーの同定 日本学術振興会 科学研究費助成事業 2023年04月01日 - 2026年03月31日 血中リン調節因子Galnt3、Fgf23遺伝子発現を制御するエンハンサーの同定 日本学術振興会 科学研究費助成事業 基盤研究(C) 2022年04月01日 - 2025年03月31日 骨芽細胞成熟過程におけるRunx2のTln2を介した突起形成制御機能の解明 日本学術振興会 科学研究費助成事業 若手研究 2019年04月01日 - 2021年03月31日 肥大軟骨細胞より骨芽細胞への分化転換におけるRunx2の役割 日本学術振興会 科学研究費助成事業 若手研究(B) 2017年04月01日 - 2019年03月31日 マウス生体でI型コラーゲン遺伝子発現を骨芽細胞特異的に制御するエンハンサーの同定 日本学術振興会 科学研究費助成事業 2023/04/01 - 2026/03/31 血中リン調節因子Galnt3、Fgf23遺伝子発現を制御するエンハンサーの同定 日本学術振興会 科学研究費助成事業 基盤研究(C) 2022/04/01 - 2025/03/31 Mechanism of the regulation of osteoblast process formation by Runx2 through Tln2 regulation during osteoblast maturation Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research 2019/04/01 - 2021/03/31 Role of Runx2 in transdifferentiation from hypertrophic chondrocytes to osteoblasts Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B) 2017/04/01 - 2019/03/31

特許	patents

社会貢献活動	social contribution

メディア報道	media_coverage

学術貢献活動	academic_contribution

その他	etc