ResearchGate	Hos

研究キーワード	research interests

研究分野	research research_areas

学歴	education	2015年02月 － 2023年06月 Leiden University Medical Center Immunology 2011年09月 － 2014年08月 Vrije Universiteit Amsterdam Life Science 2015/02 － 2023/06 Leiden University Medical Center Immunology 2011/09 － 2014/08 Vrije Universiteit Amsterdam Life Science

経歴	experience

委員歴	committee memberships

所属学協会	association memberships	Japanese Association of Cancer Immunology	Japanese Association of Cancer Immunology

受賞	awards

論文	papers	Vaccination with cationic liposome-encapsulated CD4 and CD8 T cell neoepitopes induces superior tumor control Felicia S. Spitzer,Jeroen Heuts,Brett J. Hos,Stefan Romeijn,Marcel G.M. Camps,Ferry Ossendorp,Koen van der Maaden Materials Today Bio 2026年06月 CTG-Initiated Cryptic Peptide Translation Up- and Downstream of a Canonical ATG Start Codon Is Enhanced by TLR Stimulation and Induces Tumor Regression in Mice Ziye Song,Youkyung Lim,Anneloes van Krimpen,Mitchell A.A. Geleijnse,Manon Messchendorp,Jane S.A. Voerman,Ling Li,Emma G.M. Tondeur,Gunja Mishra,Brett J. Hos,Dwin G.B. Grashof,Ralph Stadhouders,Harmen J.G. van de Werken,Peter D. Katsikis,Christopher Schliehe Cancer Immunology Research 13巻8号1246頁-1265頁 2025年06月03日 MC38 colorectal tumor cell lines from two different sources display substantial differences in transcriptome, mutanome and neoantigen expression Barbara Schrörs,Brett J. Hos,Ikra G. Yildiz,Martin Löwer,Franziska Lang,Christoph Holtsträter,Julia Becker,Mathias Vormehr,Ugur Sahin,Ferry Ossendorp,Mustafa Diken Frontiers in Immunology 2023年03月08日 Cancer-Specific T Helper Shared and Neo-Epitopes Uncovered by Expression of the MHC Class II Master Regulator CIITA Brett Jos Hos,Elena Tondini,Marcel G.M. Camps,Wesley Rademaker,Jitske van den Bulk,Dina Ruano,George M.C. Janssen,Arnoud H. de Ru,Peter J. van den Elsen,Noel F. C. C. de Miranda,Peter A. van Veelen,Ferry A. Ossendorp Cell Reports 2021年 Identification of a neo-epitope dominating endogenous CD8 T cell responses to MC-38 colorectal cancer Brett J. Hos,Marcel G.M. Camps,Jitske van den Bulk,Elena Tondini,Thomas C. van den Ende,Dina Ruano,Kees Franken,George M.C. Janssen,Arnoud Ru,Dmitri V. Filippov,Ramon Arens,Peter A. van Veelen,Noel Miranda,Ferry Ossendorp OncoImmunology 2020年01月 Approaches to Improve Chemically Defined Synthetic Peptide Vaccines Brett J. Hos Frontiers in Immunology 2018年04月26日 The Optimization of Bioorthogonal Epitope Ligation within MHC-I Complexes Brett J. Hos ACS Chemical Biology 2016年11月18日 Vaccination with cationic liposome-encapsulated CD4 and CD8 T cell neoepitopes induces superior tumor control Felicia S. Spitzer,Jeroen Heuts,Brett J. Hos,Stefan Romeijn,Marcel G.M. Camps,Ferry Ossendorp,Koen van der Maaden Materials Today Bio 2026/06 CTG-Initiated Cryptic Peptide Translation Up- and Downstream of a Canonical ATG Start Codon Is Enhanced by TLR Stimulation and Induces Tumor Regression in Mice Ziye Song,Youkyung Lim,Anneloes van Krimpen,Mitchell A.A. Geleijnse,Manon Messchendorp,Jane S.A. Voerman,Ling Li,Emma G.M. Tondeur,Gunja Mishra,Brett J. Hos,Dwin G.B. Grashof,Ralph Stadhouders,Harmen J.G. van de Werken,Peter D. Katsikis,Christopher Schliehe Cancer Immunology Research 13.8.1246-1265 2025/06/03 MC38 colorectal tumor cell lines from two different sources display substantial differences in transcriptome, mutanome and neoantigen expression Barbara Schrörs,Brett J. Hos,Ikra G. Yildiz,Martin Löwer,Franziska Lang,Christoph Holtsträter,Julia Becker,Mathias Vormehr,Ugur Sahin,Ferry Ossendorp,Mustafa Diken Frontiers in Immunology 2023/03/08 Cancer-Specific T Helper Shared and Neo-Epitopes Uncovered by Expression of the MHC Class II Master Regulator CIITA Brett Jos Hos,Elena Tondini,Marcel G.M. Camps,Wesley Rademaker,Jitske van den Bulk,Dina Ruano,George M.C. Janssen,Arnoud H. de Ru,Peter J. van den Elsen,Noel F. C. C. de Miranda,Peter A. van Veelen,Ferry A. Ossendorp Cell Reports 2021 Identification of a neo-epitope dominating endogenous CD8 T cell responses to MC-38 colorectal cancer Brett J. Hos,Marcel G.M. Camps,Jitske van den Bulk,Elena Tondini,Thomas C. van den Ende,Dina Ruano,Kees Franken,George M.C. Janssen,Arnoud Ru,Dmitri V. Filippov,Ramon Arens,Peter A. van Veelen,Noel Miranda,Ferry Ossendorp OncoImmunology 2020/01 Approaches to Improve Chemically Defined Synthetic Peptide Vaccines Brett J. Hos Frontiers in Immunology 2018/04/26 The Optimization of Bioorthogonal Epitope Ligation within MHC-I Complexes Brett J. Hos ACS Chemical Biology 2016/11/18

MISC

書籍等出版物	books

講演・口頭発表等	conference	PROTACを用いて抗原のプロテアソームによる分解を誘導し、がんに対するCTL応答を増強する。 Hos, Brett Jos 第30回日本がん免疫学会総会 2026年07月23日 PROTACを用いて抗原のプロテアソームによる分解を誘導し、がんに対するCTL応答を増強する。 Hos, Brett Jos 第30回日本がん免疫学会総会 2026年07月23日 Forcing proteasomal degradation of antigens with PROTACs to boost CTL responses against cancer. Hos, Brett Jos 30th annual meeting of Japanese Association of Cancer Immunology 2026/07/23 Forcing proteasomal degradation of antigens with PROTACs to boost CTL responses against cancer. Hos, Brett Jos 30th annual meeting of Japanese Association of Cancer Immunology 2026/07/23

担当経験のある項目	teaching experience

Works

競争的資金等の研究課題	research grants	Targeted delivery of encapsulated PROTAC for immunomodulation of the tumor microenvironment 日本学術振興会 科学研究費助成事業 2026年07月 - 2028年03月 研究代表者 Targeted delivery of encapsulated PROTAC for immunomodulation of the tumor microenvironment 日本学術振興会 科学研究費助成事業 2026/07 - 2028/03 principal_investigator

特許	patents

社会貢献活動	social contribution

メディア報道	media_coverage

学術貢献活動	academic_contribution

その他	etc