研究キーワード	research interests	薬物動態学,薬理遺伝学	薬物動態学,薬理遺伝学

研究分野	research research_areas	薬理学	Pharmacology

学歴	education	－ 2005年 九州大学 薬学研究科 － 2002年 九州大学 薬学研究科 － 2000年 九州大学 薬学部 － 2005 Kyushu University 薬学研究科 － 2002 Kyushu University 薬学研究科 － 2000 Kyushu University School of Pharmaceutical Sciences

経歴	experience

委員歴	committee memberships

所属学協会	association memberships	日本臨床薬理学会,日本医療薬学会,日本薬学会,日本薬物動態学会	日本臨床薬理学会,日本医療薬学会,日本薬学会,日本薬物動態学会

受賞	awards

論文	papers	Association Between Perioperative Daprodustat Use and Early Posttransplant Graft Function in Living Donor Kidney Transplantation: A Propensity Score-Matched Retrospective Study. Tomohiro Shigematsu,Soichiro Tajima,Hiroshi Noguchi,Takashi Ogino,Keizo Kaku,Takeshi Hirota,Mayako Uchida Current therapeutic research, clinical and experimental 105巻100837頁-100837頁 2026年12月 Identification of Urinary Exosomal microRNAs Associated With Subclinical Acute T-Cell-Mediated Rejection in Kidney Transplant Recipients. Soichiro Tajima,Miori Ono,Yuto Kawazoe,Hiroshi Noguchi,Tomohiro Shigematsu,Takashi Ogino,Shoji Nakamura,Takahiro Nakamura,Keizo Kaku,Takeshi Hirota,Ichiro Ieiri,Mayako Uchida Clinical and translational science 19巻5号e70572頁- 2026年05月 Impact of lymphocyte p-glycoprotein activity on development of graft-versus-host disease after stem cell transplantation. Shoji Nakamura,Soichiro Tajima,Takeshi Hirota,Koji Kato,Koichi Akashi,Mayako Uchida International journal of hematology 2026年04月15日 Impact of sodium-glucose cotransporter 2 (SGLT2) inhibitors on hematologic malignancy risk: Insights from Japanese claims data. Takehiro Kawashiri,Naru Yamamoto,Masaki Fujiwara,Tadashi Shimizu,Daisuke Kobayashi,Shunsuke Fujita,Nobuhito Shibata,Takeshi Hirota,Mayako Uchida Journal of the National Cancer Institute 2026年02月14日 Concomitant Use of DPP-4 Inhibitors May Prevent the Development of Oxaliplatin-Induced Peripheral Neuropathy: A Retrospective Cohort Study. Yusuke Koura,Keisuke Mine,Shunsuke Fujita,Takehiro Kawashiri,Yusuke Mori,Mami Ueda,Risa Kaneko,Takeshi Hirota,Mayako Uchida,Daisuke Kobayashi Clinical and translational science 19巻2号e70500頁- 2026年02月 Prospective study of anamorelin in pancreatic cancer cachexia: Clinical and translational insights into response heterogeneity. Ryosuke Matsukane,Haruna Minami,Nao Fujimori,Keijiro Ueda,Yasuhiro Komori,Yu Takamatsu,Takahiro Ueda,Minako Kimura,Chitose Matsuzaki,Takanori Tanaka,Aimi Morito,Saki Kuwahara,Masako Hashimoto,Satoshi Hirai,Tomiko Yokoyama,Shigeru Ishida,Takeshi Hirota,Yoshihiro Ogawa,Mayako Uchida Clinical nutrition (Edinburgh, Scotland) 58巻106581頁-106581頁 2026年01月20日 Evaluation of the association of pseudoaldosteronism with licorice-containing herbal medicine using the Japanese Adverse Drug Event Report (JADER) database Satoshi Nakao,Jun Liao,Yoko Ino,Keita Oura,Seiichiro Ito,Koichi Kageyama,Mugita Sato,Yuko Murakami,Shigeru Ishida,Takeshi Hirota,Satoshi Endo,Mayako Uchida,Kazuhiro Iguchi,Mitsuhiro Nakamura Journal of Ethnopharmacology 121202頁-121202頁 2026年01月 Effect of Probiotics on Immunosuppressive Drug Pharmacokinetics: Interaction between <i>Bacillus subtilis</i> and Tacrolimus in Mice Yuichi Tsuchiya,Nanae Yamamoto,Takeshi Yamamoto,Yoshitoshi Ogura,Takeshi Hirota,Ichiro Ieiri,Mayako Uchida Biological and Pharmaceutical Bulletin 48巻12号1911頁-1920頁 2025年12月13日 The Effect of Diabetes Medication on the Scores of the GNRI and CONUT Nutritional Indices: Cross-Sectional and Longitudinal Retrospective Studies. Shunsuke Fujita,Kenichiro Nagata,Kano Kinjo,Haruka Mimata,Taiga Sonoda,Keisuke Mine,Takehiro Kawashiri,Takeshi Hirota,Mayako Uchida,Daisuke Kobayashi Clinical and translational science 18巻11号e70423頁- 2025年11月 Adverse event profiles of four monomethyl auristatin E-conjugated antibody drug conjugates: a disproportionality analysis based on the US FDA adverse event reporting system (FAERS) database. Yohei Doi,Ichiro Ieiri,Mayako Uchida,Takeshi Hirota Expert opinion on drug safety 2025年06月27日 Association Between Perioperative Daprodustat Use and Early Posttransplant Graft Function in Living Donor Kidney Transplantation: A Propensity Score-Matched Retrospective Study. Tomohiro Shigematsu,Soichiro Tajima,Hiroshi Noguchi,Takashi Ogino,Keizo Kaku,Takeshi Hirota,Mayako Uchida Current therapeutic research, clinical and experimental 105.100837-100837 2026/12 Identification of Urinary Exosomal microRNAs Associated With Subclinical Acute T-Cell-Mediated Rejection in Kidney Transplant Recipients. Soichiro Tajima,Miori Ono,Yuto Kawazoe,Hiroshi Noguchi,Tomohiro Shigematsu,Takashi Ogino,Shoji Nakamura,Takahiro Nakamura,Keizo Kaku,Takeshi Hirota,Ichiro Ieiri,Mayako Uchida Clinical and translational science 19.5.e70572- 2026/05 Impact of lymphocyte p-glycoprotein activity on development of graft-versus-host disease after stem cell transplantation. Shoji Nakamura,Soichiro Tajima,Takeshi Hirota,Koji Kato,Koichi Akashi,Mayako Uchida International journal of hematology 2026/04/15 Impact of sodium-glucose cotransporter 2 (SGLT2) inhibitors on hematologic malignancy risk: Insights from Japanese claims data. Takehiro Kawashiri,Naru Yamamoto,Masaki Fujiwara,Tadashi Shimizu,Daisuke Kobayashi,Shunsuke Fujita,Nobuhito Shibata,Takeshi Hirota,Mayako Uchida Journal of the National Cancer Institute 2026/02/14 Concomitant Use of DPP-4 Inhibitors May Prevent the Development of Oxaliplatin-Induced Peripheral Neuropathy: A Retrospective Cohort Study. Yusuke Koura,Keisuke Mine,Shunsuke Fujita,Takehiro Kawashiri,Yusuke Mori,Mami Ueda,Risa Kaneko,Takeshi Hirota,Mayako Uchida,Daisuke Kobayashi Clinical and translational science 19.2.e70500- 2026/02 Prospective study of anamorelin in pancreatic cancer cachexia: Clinical and translational insights into response heterogeneity. Ryosuke Matsukane,Haruna Minami,Nao Fujimori,Keijiro Ueda,Yasuhiro Komori,Yu Takamatsu,Takahiro Ueda,Minako Kimura,Chitose Matsuzaki,Takanori Tanaka,Aimi Morito,Saki Kuwahara,Masako Hashimoto,Satoshi Hirai,Tomiko Yokoyama,Shigeru Ishida,Takeshi Hirota,Yoshihiro Ogawa,Mayako Uchida Clinical nutrition (Edinburgh, Scotland) 58.106581-106581 2026/01/20 Evaluation of the association of pseudoaldosteronism with licorice-containing herbal medicine using the Japanese Adverse Drug Event Report (JADER) database Satoshi Nakao,Jun Liao,Yoko Ino,Keita Oura,Seiichiro Ito,Koichi Kageyama,Mugita Sato,Yuko Murakami,Shigeru Ishida,Takeshi Hirota,Satoshi Endo,Mayako Uchida,Kazuhiro Iguchi,Mitsuhiro Nakamura Journal of Ethnopharmacology 121202-121202 2026/01 Effect of Probiotics on Immunosuppressive Drug Pharmacokinetics: Interaction between <i>Bacillus subtilis</i> and Tacrolimus in Mice Yuichi Tsuchiya,Nanae Yamamoto,Takeshi Yamamoto,Yoshitoshi Ogura,Takeshi Hirota,Ichiro Ieiri,Mayako Uchida Biological and Pharmaceutical Bulletin 48.12.1911-1920 2025/12/13 The Effect of Diabetes Medication on the Scores of the GNRI and CONUT Nutritional Indices: Cross-Sectional and Longitudinal Retrospective Studies. Shunsuke Fujita,Kenichiro Nagata,Kano Kinjo,Haruka Mimata,Taiga Sonoda,Keisuke Mine,Takehiro Kawashiri,Takeshi Hirota,Mayako Uchida,Daisuke Kobayashi Clinical and translational science 18.11.e70423- 2025/11 Adverse event profiles of four monomethyl auristatin E-conjugated antibody drug conjugates: a disproportionality analysis based on the US FDA adverse event reporting system (FAERS) database. Yohei Doi,Ichiro Ieiri,Mayako Uchida,Takeshi Hirota Expert opinion on drug safety 2025/06/27 さらに表示する more

MISC

がん悪液質治療薬アナモレリンの治療効果・副作用の前向き観察研究 松金 良祐,南 晴奈,桑原 咲,橋本 全子,末次 王卓,廣田 豪,植田 圭二郎,藤森 尚,小川 佳宏,家入 一郎 膵臓 38巻3号A427頁-A427頁 2023年07月 SULFASALAZINE DISPOSITION IN SUBJECT WITH 376C>T (NONSENSE MUTATION) VARIANT IN ABCG2 GENE Takeshi Hirota,Keisuke Gotanda,Tomoko Tokumoto,Masato Fukae,Ichiro Ieiri DRUG METABOLISM AND PHARMACOKINETICS 32巻1号S104頁-S104頁 2017年01月 Sulfasalazine disposition in a subject with 376C > T (nonsense mutation) and 421C > A variants in the ABCG2 gene Keisuke Gotanda,Tomoko Tokumoto,Takeshi Hirota,Masato Fukae,Ichiro Ieiri BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 80巻5号1236頁-1237頁 2015年11月 Drug-drug interactions that interfere with statin metabolism Takeshi Hirota,Ichiro Ieiri Expert Opinion on Drug Metabolism and Toxicology 11巻9号1435頁-1447頁 2015年09月02日 Neonatal Dubin-Johnson syndrome: novel compound heterozygous mutation in the ABCC2 gene. Hitoshi Okada,Takashi Kusaka,Noriko Fuke,Jun Kunikata,Sonoko Kondo,Takashi Iwase,Wang Nan,Takeshi Hirota,Ichiro Ieiri,Susumu Itoh Pediatrics international : official journal of the Japan Pediatric Society 56巻5号e62-4頁-e64頁 2014年10月 Epigenetic regulation of genes encoding drug-metabolizing enzymes and transporters; DNA methylation and other mechanisms Takeshi Hirota,Hiroshi Takane,Shun Higuchi,Ichiro Ieiri CURRENT DRUG METABOLISM 9巻1号34頁-38頁 2008年01月 PHARMACOGENETIC CHARACTERIZATION OF SULFASALAZINE BASED ON THE DRUG METABOLIZING ENZYME (NAT2) AND TRANSPORTER (BCRP, ABCG2) GENE POLYMORPHISMS IN HUMANS Yumiko Yamasaki,Ichiro Ieiri,Hiroyuki Kusuhara,Tomohiro Sasaki,Miyuki Kimura,Hiroko Tabuchi,Kazuya Maeda,Takeshi Hirota,Yukie Ando,Shin Irie,Joseph Alan Ware,Yuichi Sugiyama,Shun Higuchi DRUG METABOLISM REVIEWS 39巻267頁-268頁 2007年 Genetic polymorphisms of drug transporters: pharmacokinetic and pharmacodynamic consequences in pharmacotherapy Ichiro Ieiri,Hiroshi Takane,Takeshi Hirota,Kenji Otsubo,Shun Higuchi EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY 2巻5号651頁-674頁 2006年10月 Functional assessment of ABCG2 (BCRP) gene polymorphisms to protein expression in human placenta D Kobayashi,Ieiri, I,T Hirota,H Takane,S Maegawa,J Kigawa,H Suzuki,E Nanba,M Oshimura,N Terakawa,K Otsubo,K Mine,Y Sugiyama DRUG METABOLISM AND DISPOSITION 33巻1号94頁-101頁 2005年01月 Allelic expression imbalance of the human CYP3A4 gene and individual phenotypic status T Hirota,Ieiri, I,H Takane,S Maegawa,M Hosokawa,K Kobayashi,K Chiba,E Nanba,M Oshimura,T Sato,S Higuchi,K Otsubo HUMAN MOLECULAR GENETICS 13巻23号2959頁-2969頁 2004年12月 松金 良祐,南 晴奈,桑原 咲,橋本 全子,末次 王卓,廣田 豪,植田 圭二郎,藤森 尚,小川 佳宏,家入 一郎 膵臓 38.3.A427-A427 2023/07 SULFASALAZINE DISPOSITION IN SUBJECT WITH 376C>T (NONSENSE MUTATION) VARIANT IN ABCG2 GENE Takeshi Hirota,Keisuke Gotanda,Tomoko Tokumoto,Masato Fukae,Ichiro Ieiri DRUG METABOLISM AND PHARMACOKINETICS 32.1.S104-S104 2017/01 Sulfasalazine disposition in a subject with 376C > T (nonsense mutation) and 421C > A variants in the ABCG2 gene Keisuke Gotanda,Tomoko Tokumoto,Takeshi Hirota,Masato Fukae,Ichiro Ieiri BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 80.5.1236-1237 2015/11 Drug-drug interactions that interfere with statin metabolism Takeshi Hirota,Ichiro Ieiri Expert Opinion on Drug Metabolism and Toxicology 11.9.1435-1447 2015/09/02 Neonatal Dubin-Johnson syndrome: novel compound heterozygous mutation in the ABCC2 gene. Hitoshi Okada,Takashi Kusaka,Noriko Fuke,Jun Kunikata,Sonoko Kondo,Takashi Iwase,Wang Nan,Takeshi Hirota,Ichiro Ieiri,Susumu Itoh Pediatrics international : official journal of the Japan Pediatric Society 56.5.e62-4-e64 2014/10 Epigenetic regulation of genes encoding drug-metabolizing enzymes and transporters; DNA methylation and other mechanisms Takeshi Hirota,Hiroshi Takane,Shun Higuchi,Ichiro Ieiri CURRENT DRUG METABOLISM 9.1.34-38 2008/01 PHARMACOGENETIC CHARACTERIZATION OF SULFASALAZINE BASED ON THE DRUG METABOLIZING ENZYME (NAT2) AND TRANSPORTER (BCRP, ABCG2) GENE POLYMORPHISMS IN HUMANS Yumiko Yamasaki,Ichiro Ieiri,Hiroyuki Kusuhara,Tomohiro Sasaki,Miyuki Kimura,Hiroko Tabuchi,Kazuya Maeda,Takeshi Hirota,Yukie Ando,Shin Irie,Joseph Alan Ware,Yuichi Sugiyama,Shun Higuchi DRUG METABOLISM REVIEWS 39.267-268 2007 Genetic polymorphisms of drug transporters: pharmacokinetic and pharmacodynamic consequences in pharmacotherapy Ichiro Ieiri,Hiroshi Takane,Takeshi Hirota,Kenji Otsubo,Shun Higuchi EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY 2.5.651-674 2006/10 Functional assessment of ABCG2 (BCRP) gene polymorphisms to protein expression in human placenta D Kobayashi,Ieiri, I,T Hirota,H Takane,S Maegawa,J Kigawa,H Suzuki,E Nanba,M Oshimura,N Terakawa,K Otsubo,K Mine,Y Sugiyama DRUG METABOLISM AND DISPOSITION 33.1.94-101 2005/01 Allelic expression imbalance of the human CYP3A4 gene and individual phenotypic status T Hirota,Ieiri, I,H Takane,S Maegawa,M Hosokawa,K Kobayashi,K Chiba,E Nanba,M Oshimura,T Sato,S Higuchi,K Otsubo HUMAN MOLECULAR GENETICS 13.23.2959-2969 2004/12 さらに表示する more

書籍等出版物	books

講演・口頭発表等	conference

担当経験のある項目	teaching experience

Works

競争的資金等の研究課題	research grants	薬物動態関連遺伝子における個体間変動の要因解析 体液中臓器特異的miRNAに注目した病態時における体内・薬効動態変動の機序解明 日本学術振興会 科学研究費助成事業 2021年04月01日 - 2024年03月31日 血漿中miRNA情報を付加した治療薬物モニタリングの個別化精度向上を目指す新展開 日本学術振興会 科学研究費助成事業 2021年07月09日 - 2023年03月31日 生活習慣病に伴う薬物動態変動を反映したバイオマーカーの定量的モデル解析 日本学術振興会 科学研究費助成事業 2020年04月01日 - 2023年03月31日 エピトランスクリプトーム解析による生活習慣病のトランスポーター発現変動機構の解明 日本学術振興会 科学研究費助成事業 2019年06月28日 - 2021年03月31日 DNAメチル化によるCYP3A4活性評価法と標的メタボローム解析による臨床応用 日本学術振興会 科学研究費助成事業 2017年04月01日 - 2020年03月31日 インスリンによる薬物トランスポーター発現変動機構の解明とその機能変動予測法の確立 日本学術振興会 科学研究費助成事業 2017年04月01日 - 2020年03月31日 生体試料中miRNA濃度測定による薬物代謝酵素・トランスポーターの臓器別機能予測 日本学術振興会 科学研究費助成事業 2015年04月01日 - 2017年03月31日 ＤＮＡメチル化頻度をバイオマーカーとしたCYP3A4活性評価の臨床応用 日本学術振興会 科学研究費助成事業 2014年04月01日 - 2017年03月31日 環境要因による変動を反映する薬物トランスポーター機能予測バイオマーカーの確立 日本学術振興会 科学研究費助成事業 2014年04月01日 - 2017年03月31日 薬物動態関連遺伝子における個体間変動の要因解析 体液中臓器特異的miRNAに注目した病態時における体内・薬効動態変動の機序解明 日本学術振興会 科学研究費助成事業 2021/04/01 - 2024/03/31 血漿中miRNA情報を付加した治療薬物モニタリングの個別化精度向上を目指す新展開 日本学術振興会 科学研究費助成事業 2021/07/09 - 2023/03/31 生活習慣病に伴う薬物動態変動を反映したバイオマーカーの定量的モデル解析 日本学術振興会 科学研究費助成事業 2020/04/01 - 2023/03/31 Mechanism of regulation of drug transporter expression in lifestyle-related diseases by epitranscriptomics Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research 2019/06/28 - 2021/03/31 Evaluation between CYP3A4 activity and DNA methylation Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research 2017/04/01 - 2020/03/31 Elucidation of the mechanism of insulin-induced changes in the expression of drug transporters and the establishment of a method to predict the changes in genetic function Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research 2017/04/01 - 2020/03/31 Analysis of miRNA as a novel biomarker for estimating transporter's function in the human organs Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research 2015/04/01 - 2017/03/31 DNA methylation biomarkers for estimation of the activity of CYP3A4 in human livers Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research 2014/04/01 - 2017/03/31 Identification of endogenous biomarkers to predict the altered activities of drug transporters by environmental factors Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research 2014/04/01 - 2017/03/31 さらに表示する more

特許	patents

社会貢献活動	social contribution

メディア報道	media_coverage

学術貢献活動	academic_contribution

その他	etc