研究キーワード	research interests	免疫代謝,脂肪代謝,老化,長寿	immunometabolism,Adipose tissue metabolism,Aging,Longevity

研究分野	research research_areas	分子生物学	Molecular biology

学歴	education	2005年04月 － 2009年03月 長崎大学 医歯薬学総合研究科 2005/04 － 2009/03 Nagasaki University 医歯薬学総合研究科

経歴	experience	2024年11月 － 長崎大学 講師 2012年04月 － 2024年10月 長崎大学 助教 2009年04月 － 2012年03月 Scripps Institute Department of Metabolism and Aging Research Associate 2024/11 － Nagasaki University 講師 2012/04 － 2024/10 Nagasaki University 助教 2009/04 － 2012/03 Scripps Institute Department of Metabolism and Aging Research Associate

委員歴	committee memberships	2023年04月 － 2025年03月 長崎大学 医学部医学科博士編入 生命科学系科目出題委員 2023/04 － 2025/03 長崎大学 医学部医学科博士編入 生命科学系科目出題委員

所属学協会	association memberships

受賞	awards

論文	papers	ZFP90 Serves as a Transcriptional Brake on NF-κB Signaling to Attenuate Diet-Induced MASLD Progression. Park S.,Komatsu T.,Misumi K.,Okuzaki D.,Shimokawa I. Nutrients 18巻14号2332頁- 2026年07月 Hepatic FoxO3 supports metabolic resilience, attenuates age-associated obesity and metabolic dysfunction, and mitigates diet-induced steatohepatitis. Komatsu T.,Park S.,Kim SE,Hayashi H.,Shimokawa I. Aging and Disease 18巻5号 2026年07月 Influence of Adipokines on Metabolic Dysfunction and Aging Seongjoon Park,Isao Shimokawa Biomedicines 12巻873号 2024年04月 The Role of Neuropeptide Y in Adipocyte-Macrophage Crosstalk during High Fat Diet-Induced Adipose Inflammation and Liver Steatosis Seongjoon Park,Toshimitsu Komatsu,Hiroko Hayashi,Ryoichi Mori,Isao Shimokawa Biomedicines 9巻11号1739頁-1739頁 2021年11月22日 NPY deficiency prevents postmenopausal adiposity by augmenting estradiol-mediated browning. Park S,Nayantai E,Komatsu T,Hayashi H,Mori R,Shimokawa I The journals of gerontology. Series A, Biological sciences and medical sciences 75巻6号1042頁-1049頁 2020年05月 Mechanisms of Calorie Restriction: A Review of Genes Required for the life-Extending and Tumor-Inhibiting Effects of calorie Restriction 下川 功 Nutrients 2019年12月 Effects of rikkunshito supplementation on resistance to oxidative stress and lifespan in mice 王,下川 功,千葉卓哉 Geriatrics Gerontology International 1頁-10頁 2019年12月 Neuropeptide Y inhibits hepatocarcinogenesis in overnutrition in mice. Ayaka Kinoshita, Hiroko Hayashi, Natsuho Kusano, Shun Inoue, Toshimitsu Komatsu, Ryoichi Mori, Seongjoon Park, Mitsuhisa Takatsuki, Susumu Eguchi, Isao Shimokawa Acta Med Nagasaki 63巻11頁-15頁 2019年11月 Targeting miR-223 in neutrophils enhances the clearance of Staphylococcus aureus in infected wounds. Maiko de Kerckhove,Katsuya Tanaka,Takahiro Umehara,Momoko Okamoto,Sotaro Kanematsu,Hiroko Hayashi,Hiroki Yano,Soushi Nishiura,Shiho Tooyama,Yutaka Matsubayashi,Toshimitsu Komatsu,Seongjoon Park,Yuka Okada,Rina Takahashi,Yayoi Kawano,Takehisa Hanawa,Keisuke Iwasaki,Tadashige Nozaki,Hidetaka Torigoe,Kazuya Ikematsu,Yutaka Suzuki,Katsumi Tanaka,Paul Martin,Isao Shimokawa,Ryoichi Mori EMBO molecular medicine 10巻10号 2018年10月 Comparing the Effects of Melatonin with Caloric Restriction in the Hippocampus of Aging Mice: Involvement of Sirtuin1 and the FOXOs Pathway Anorut Jenwitheesuk,Seongjoon Park,Prapimpun Wongchitrat,Jiraporn Tocharus,Sujira Mukda,Isao Shimokawa,Piyarat Govitrapong Neurochemical Research 43巻1号144頁-152頁 2018年01月01日 ZFP90 Serves as a Transcriptional Brake on NF-κB Signaling to Attenuate Diet-Induced MASLD Progression. Park S.,Komatsu T.,Misumi K.,Okuzaki D.,Shimokawa I. Nutrients 18.14.2332- 2026/07 Hepatic FoxO3 supports metabolic resilience, attenuates age-associated obesity and metabolic dysfunction, and mitigates diet-induced steatohepatitis. Komatsu T.,Park S.,Kim SE,Hayashi H.,Shimokawa I. Aging and Disease 18.5. 2026/07 Influence of Adipokines on Metabolic Dysfunction and Aging Seongjoon Park,Isao Shimokawa Biomedicines 12.873. 2024/04 The Role of Neuropeptide Y in Adipocyte-Macrophage Crosstalk during High Fat Diet-Induced Adipose Inflammation and Liver Steatosis Seongjoon Park,Toshimitsu Komatsu,Hiroko Hayashi,Ryoichi Mori,Isao Shimokawa Biomedicines 9.11.1739-1739 2021/11/22 NPY deficiency prevents postmenopausal adiposity by augmenting estradiol-mediated browning. Park S,Nayantai E,Komatsu T,Hayashi H,Mori R,Shimokawa I The journals of gerontology. Series A, Biological sciences and medical sciences 75.6.1042-1049 2020/05 Mechanisms of Calorie Restriction: A Review of Genes Required for the life-Extending and Tumor-Inhibiting Effects of calorie Restriction Komatsu T,Park S,Hayashi H,Mori R,Yamaza H,Shimokawa I Nutrients 2019/12 Effects of rikkunshito supplementation on resistance to oxidative stress and lifespan in mice Zi Wang,Toshimitsu Komatsu,Yoshihisa Ohata,Yukari Watanabe,Yiwen Yuan,Yuki Yoshii,Seongjoon Park,Ryoichi Mori,Motoyasu Satou,Yoshitaka Kondo,Isao Shimokawa,Takuya Chiba Geriatrics Gerontology International 1-10 2019/12 Neuropeptide Y inhibits hepatocarcinogenesis in overnutrition in mice. Ayaka Kinoshita, Hiroko Hayashi, Natsuho Kusano, Shun Inoue, Toshimitsu Komatsu, Ryoichi Mori, Seongjoon Park, Mitsuhisa Takatsuki, Susumu Eguchi, Isao Shimokawa Acta Med Nagasaki 63.11-15 2019/11 Targeting miR-223 in neutrophils enhances the clearance of Staphylococcus aureus in infected wounds. Maiko de Kerckhove,Katsuya Tanaka,Takahiro Umehara,Momoko Okamoto,Sotaro Kanematsu,Hiroko Hayashi,Hiroki Yano,Soushi Nishiura,Shiho Tooyama,Yutaka Matsubayashi,Toshimitsu Komatsu,Seongjoon Park,Yuka Okada,Rina Takahashi,Yayoi Kawano,Takehisa Hanawa,Keisuke Iwasaki,Tadashige Nozaki,Hidetaka Torigoe,Kazuya Ikematsu,Yutaka Suzuki,Katsumi Tanaka,Paul Martin,Isao Shimokawa,Ryoichi Mori EMBO molecular medicine 10.10. 2018/10 Comparing the Effects of Melatonin with Caloric Restriction in the Hippocampus of Aging Mice: Involvement of Sirtuin1 and the FOXOs Pathway Anorut Jenwitheesuk,Seongjoon Park,Prapimpun Wongchitrat,Jiraporn Tocharus,Sujira Mukda,Isao Shimokawa,Piyarat Govitrapong Neurochemical Research 43.1.144-152 2018/01/01 さらに表示する more

MISC	Ghrelin and its receptor (GHS-R): Recent progress Roy G. Smith,Andras Kern,Nicole H. Rogers,Heidi Walsh,Rosie Albarran-Zeckler,Bryan Wharram,Seongjoon Park ENDOCRINE JOURNAL 57巻S229頁-S229頁 2010年03月 Ghrelin and its receptor (GHS-R): Recent progress Roy G. Smith,Andras Kern,Nicole H. Rogers,Heidi Walsh,Rosie Albarran-Zeckler,Bryan Wharram,Seongjoon Park ENDOCRINE JOURNAL 57.S229-S229 2010/03

書籍等出版物	books	加齢と栄養、「総説」栄養と加齢―基礎的研究より, 森 亮一,朴 盛浚,下川 功 2018年 Aging Mechanisms; Longevity, Metabolism, and Brain Aging; Role of the Forkhead Box O Family and Neuropeptide Y in Calorie Restriction. Mori R,Park S,Shimokawa I Springer 2015年 Aging and Nutrition Mori R,Park S,Shimokawa I 2018 Aging Mechanisms; Longevity, Metabolism, and Brain Aging; Role of the Forkhead Box O Family and Neuropeptide Y in Calorie Restriction. Mori R,Park S,Shimokawa I Springer 2015

講演・口頭発表等	conference	ZFP90欠損は炎症および代謝異常を通じてMASLDの進行を促進させる Seongjoon Park,Toshimitsu Komatsu,Isao Shimokawa 日本分子生物学会 2025年12月04日 Absence of ZFP90 aggravates obesity-related non-alcoholic fatty liver disease through immune dysregulation Seongjoon Park 日本分子生物学会 2024年11月25日 The emerging role of ZFP90-mediated immunometabolism in the obesity related non-alcoholic fatty liver disease Seongjoon Park 日本分子生物学会 2023年12月06日 The emerging role of ZFP90-mediated immunometabolism in the obesity related non-alcoholic fatty liver disease. Seongjoon Park The Pusan-Nagasaki Joint Symposium on Aging Research 2023年02月17日 Critical role of NPY in the lipid metabolic homeostasis under negative energy balance Park Seongjoon Würzburg-Nagasaki Digital Seasonal Symposium 2021, ‘Healthy aging’ 2021年06月24日 ZFP90 as a multitasking player in the protection of obesity related non-alcoholic fatty liver disease. Park Seongjoon The 44th Annual Congress of the Japan Society for Biomedical Gerontology 2021年06月12日 Deletion of ZFP90 accelerates high fat diet-induced fatty liver. Park Seongjoon The 110th Annual Congress of the Japanese Society of Pathology 2021年04月22日 Regulation of fat utilization and adiposity by NPY deficiency in female mice. Park Seongjoon The 42th Annual Congress of the Japan Society for Biomedical Gerontology 2019年06月 Regulation of high fat diet-induced lipid metabolic dysfunctions by NPY deficiency: role of increasing fat utilization and attenuating inflammation Park Seongjoon The 108th Annual Congress of the Japanese Society of Pathology 2019年05月 Correlation between neuropeptide Y and estrogen in the regulation of adipose tissue metabolism. Park Seongjoon The 107th Annual Congress of the Japanese Society of Pathology 2018年06月 ZFP90 deficiency promotes MASLD progression through inflammatory and metabolic dysregulation Seongjoon Park,Toshimitsu Komatsu,Isao Shimokawa The 48th Annual Congress of the Japanese Society of Molecular Biology 2025/12/04 Absence of ZFP90 aggravates obesity-related non-alcoholic fatty liver disease through immune dysregulation Seongjoon Park The Molecular Biology Society of Japan 2024/11/25 The emerging role of ZFP90-mediated immunometabolism in the obesity related non-alcoholic fatty liver disease Seongjoon Park The molecular biology society of Japan 2023/12/06 The emerging role of ZFP90-mediated immunometabolism in the obesity related non-alcoholic fatty liver disease. Seongjoon Park The Pusan-Nagasaki Joint Symposium on Aging Research 2023/02/17 Critical role of NPY in the lipid metabolic homeostasis under negative energy balance Park Seongjoon Würzburg-Nagasaki Digital Seasonal Symposium 2021, ‘Healthy aging’ 2021/06/24 ZFP90 as a multitasking player in the protection of obesity related non-alcoholic fatty liver disease. Park Seongjoon The 44th Annual Congress of the Japan Society for Biomedical Gerontology 2021/06/12 Deletion of ZFP90 accelerates high fat diet-induced fatty liver. Park Seongjoon The 110th Annual Congress of the Japanese Society of Pathology 2021/04/22 Regulation of fat utilization and adiposity by NPY deficiency in female mice. Park Seongjoon The 42th Annual Congress of the Japan Society for Biomedical Gerontology 2019/06 Regulation of high fat diet-induced lipid metabolic dysfunctions by NPY deficiency: role of increasing fat utilization and attenuating inflammation Park Seongjoon The 108th Annual Congress of the Japanese Society of Pathology 2019/05 Correlation between neuropeptide Y and estrogen in the regulation of adipose tissue metabolism. Park Seongjoon The 107th Annual Congress of the Japanese Society of Pathology 2018/06 さらに表示する more

担当経験のある項目	teaching experience	病理総論実習,病理総論,初年次セミナー,モジュール,先端機器実習,医学ゼミ,病理学	病理総論実習,病理総論,初年次セミナー,モジュール,先端機器実習,医学ゼミ,病理学

Works

競争的資金等の研究課題	research grants	健康寿命延伸の鍵を握る脂質代謝の性差から見たマクロファージ由来NPYの役割 文部科学省科学研究費補助金基盤研究（C） 2024年04月 - 2027年03月 研究代表者 次世代老化制御ターゲットと作用物質の探索」に関する共同研究契約 2024年度 合同会社SAGLとの共同研究 2024年04月 - 2025年03月 研究代表者 FoxO転写因子による癌と老化の制御機構とその制御化合物の探索 日本学術振興会 科学研究費助成事業 2015年04月 - 2019年03月 脂肪代謝でのNPYの抗老化関連分子メカ二ズム確立 文部科学省科学研究費補助金若手研究（B） 2015年04月 - 2018年03月 研究代表者 Financial Support for Overseas Travel Expenses of Medical Scholars from Japan The Ichiro Kanehara Foundation 2017年 - 2018年 研究代表者 健康寿命延伸の鍵を握る脂質代謝の性差から見たマクロファージ由来NPYの役割 文部科学省科学研究費補助金基盤研究（C） 2024/04 - 2027/03 principal_investigator 次世代老化制御ターゲットと作用物質の探索」に関する共同研究契約 2024年度 合同会社SAGLとの共同研究 2024/04 - 2025/03 principal_investigator Regulation of cancer and aging by FoxO and investigation of compounds for regulation of FoxO Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research 2015/04 - 2019/03 Establishment of anti-aging mechanisms by NPY in the fat metabolism Japan Society for the Promotion of Science 2015/04 - 2018/03 principal_investigator Financial Support for Overseas Travel Expenses of Medical Scholars from Japan The Ichiro Kanehara Foundation 2017 - 2018 principal_investigator

特許	patents

社会貢献活動	social contribution

メディア報道	media_coverage

学術貢献活動	academic_contribution

その他	etc